This is an ongoing project at the FitzGerald lab, which aims to examine the following topics:
1. Exercise training, exercise tolerance, ageing and circadian biology of skeletal muscle.
2. Sexual dimorphism in the response to chronic circadian misalignment.
1. Exercise training, exercise tolerance, ageing and circadian biology of skeletal muscle.
2. Sexual dimorphism in the response to chronic circadian misalignment.
Project Updates 2022-2024:
Review: Intersection of sex and circadian biology - September 2025
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A review article in the journal Current Opinion in Physiology regarding updates in sexually dimorphic research in circadian biology
Invited Conference Talk: Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, PA, USA - July 2024
Talk title: Endurance exercise training partially rescues aged metabolic phenotypes and improves health span in mice lacking a functional circadian clock.
Presented at the Spring 2025 Pennsylvania Muscle Institute - From Molecules to Movement: Cytoskeletal Insights into Muscle Function and Neuronal Health.
Presented at the Spring 2025 Pennsylvania Muscle Institute - From Molecules to Movement: Cytoskeletal Insights into Muscle Function and Neuronal Health.
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PMI Poster Session 2025
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Presenting at PMI 2025
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PMI Symposium 2025
Journal Club Paper: Sex and the clock: Time to consider sexually dimorphic rhythms in circadian research - March 2025
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A Journal Club Article in the Journal of Biological Rhythms regarding sexually dimorphic rhythms in sleep architecture.
Preprint: Brown adipose tissue thermogenesis rhythms are driven by the SCN independent of adipocyte clocks - October 2024
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Bioxiv Preprint led by Dr Georgios Paschos in the FitzGerald Lab.
Journal Club Paper: The dark side of shift work: circadian misalignment of skeletal muscle - September 2023
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A Journal Club Article in Nature Reviews Endocrinology regarding shift work and muscle metabolism.
Research Seminar: Royal College of Surgeons, Dublin, Ireland, (RCSI) - July 2024
Talk title: The crucial links between circadian rhythms, metabolism, exercise, and aging
Hosted by Dr Cristina Ruedell Reschke & Dr Annie Curtis, School of Pharmacy and Biomolecular Sciences, RCSI, Dublin, Ireland.
Hosted by Dr Cristina Ruedell Reschke & Dr Annie Curtis, School of Pharmacy and Biomolecular Sciences, RCSI, Dublin, Ireland.
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Networking with Dr Cristina Ruedell Reschke & team.
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Presenting at the Royal College of Surgeons, Dublin, Ireland.
Invited Seminar: University of Limerick, Ireland, Department of Biological Sciences - July 2024
Talk title: Biology around the clock: Circadian rhythms in metabolism, exercise, and aging
Hosted by Di Eibhlis O' Conner the Department of Biological Sciences, University of Limerick, Ireland.
Hosted by Di Eibhlis O' Conner the Department of Biological Sciences, University of Limerick, Ireland.
Conference: International Biochemistry of Exercise Conference, University of Limerick, Ireland - IBEC, July 2024
Poster: Endurance exercise training rescues metabolic phenotypes in mice lacking a function circadian clock
Invited Conference Talk: CSI Research Retreat, University of Pennsylvania, Philadelphia, PA, USA - October, 2023.
Talk title: The timing of Bmal1 deletion differentially impacts skeletal muscle morphology, function, and features of aging.
Presented at the Chronobiology and Sleep Institute (CSI) Research Retreat, Rubenstein Auditorium, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Presented at the Chronobiology and Sleep Institute (CSI) Research Retreat, Rubenstein Auditorium, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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Presenting at the CSI 2023 Retreat
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Q&A session at the CSI retreat
Conference: Advances in Skeletal Muscle Conference, University of Florida Myology Institute, Gainesville, FL, USA - March, 2023.
Winner of the Aurora Scientific Outstanding Poster Award for the project titled: The timing of Bmal1 deletion differentially impacts skeletal muscle morphology, function, and features of aging
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Aurora Scientific Outstanding Poster Award
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University of Florida, Gainesville, Florida
Paper: Sexual dimorphism in the response to chronic circadian misalignment on a high-fat diet - Published in Science Translational Medicine - May 2023
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Study led by Dr Sean Anderson, FitzGerald Lab, Penn.
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Sexual dimorphism in the response to chronic circadian misalignment on a high-fat diet
Review: The circadian biology of heart failure - January 2023
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A review led by Dr Nadim El Jamal, FitzGerald Lab, UPenn.
Research Paper: Circadian disruption in lung fibroblasts enhances NF-kB activity to exacerbate neutrophil recruitment - January 2023
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Study led by Dr Shannon Cox from the Curtis Lab, in RCSI, Dublin, Ireland.
Perelman School of Medicine Postdoctoral Research Seminar April 2022
Poster presentation April 2022
Title: Timing of Bmal1 deletion differentially impacts skeletal muscle morphology and function
Title: Timing of Bmal1 deletion differentially impacts skeletal muscle morphology and function
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Dr Ronan Lordan poster presentation at the University of Pennsylvania, Perelman School of Medicine Postdoc Symposium. April 2022.
Invited Seminar: University of Limerick, Department of Biological Sciences - July 2022
Title: The complex role of Bmal1 and the circadian clock in metabolism and aging
Hosted by Dr Ioannis Zabetakis, Bernal Institute, University of Limerick, Ireland.